Filed Pursuant to Rule 424(b)(5)
Registration No. 333-277434
Prospectus Supplement
to Prospectus dated February 28, 2024
Easterly Government Properties, Inc.
$300,000,000

Common Stock
We have entered into separate amended and restated equity distribution agreements, dated August 4, 2026 (each, an “equity distribution agreement” and, collectively, the “equity distribution agreements”), for a continuous offering program with each of Citigroup Global Markets Inc., BMO Capital Markets Corp., BTIG, LLC, Compass Point Research and Trading, LLC, Jefferies LLC, Raymond James & Associates, Inc., RBC Capital Markets, LLC, Truist Securities, Inc. and Wells Fargo Securities, LLC (and certain of their respective affiliates or agents). We refer to these entities, when acting in their capacity as sales agents for us or as principals, individually, as a “Sales Agent” and, collectively, as the “Sales Agents,” and we refer to these entities (or their affiliate or agent or, in the case of BTIG, LLC, Nomura Securities International, Inc. (acting through BTIG, LLC as agent)) when acting in their capacity as agents for the Forward Purchasers (as defined below), individually, as a “Forward Seller” and, collectively, as the “Forward Sellers.” In accordance with the terms of the equity distribution agreements, we may from time to time offer and sell shares of our common stock, $0.01 par value per share (“common stock”), having an aggregate offering price of up to $300,000,000 through the Sales Agents, acting as our sales agents, through the Forward Sellers, acting as agents for the relevant Forward Purchasers, or directly to the Sales Agents, acting as principals.
Sales of the shares of our common stock pursuant to the equity distribution agreements were previously registered pursuant to a Registration Statement on Form S-3 (File No. 333-277434) and a prospectus supplement dated February 28, 2024, as supplemented by supplement no. 1 dated August 1, 2024. This prospectus supplement supersedes such prospectus supplement dated February 28, 2024 with respect to the shares of our common stock offered pursuant to the equity distribution agreements. As of the date of this prospectus supplement, shares of common stock having an aggregate offering price of $85,017,692 have been offered and sold pursuant to the equity distribution agreements and, accordingly, shares of common stock having an aggregate offering price of up to $214,982,308 remain available for offer and sale, from time to time, pursuant to the equity distribution agreements, this prospectus supplement and the accompanying prospectus.
Sales of the shares of our common stock, if any, under this prospectus supplement and the accompanying prospectus made through the Sales Agents, acting as our sales agents, through the Forward Sellers, acting as agents for the relevant Forward Purchasers, or directly to the Sales Agents, acting as principals, pursuant to the equity distribution agreements, may be made in privately negotiated transactions, which may include block trades, or transactions that are deemed to be “at the market” offerings as defined in Rule 415 under the Securities Act of 1933, as amended (the “Securities Act”), including, without limitation, sales made directly on the New York Stock Exchange (the “NYSE”), on any other existing trading market for our common stock or to or through a market maker, or as otherwise may be agreed between us and the applicable Sales Agent. None of the Sales Agents or the

